Shen M, Shen B
Institute of Forensic Science, Ministry of Justice, PRC, Shanghai.
Fa Yi Xue Za Zhi. 1997;13(4):200-2, 253.
The methods using microwave irradiation for rapid preparation of acetyl, trifluoroacetyl, pentafluoropyl, heptafluorobutyl and MSTFA derivatives of Morphine, AMP and MAMP were developed. Conventional techniques for the reaction mixture to be heated need 30 min at 60-70 degrees C to form derivatizations, but by microwave irradiation, only 2-3 min is needed. The mass spectral fragmentation patterns and gas chromatographic retention times of the derivatives obtained by both microwave irradiation and conventional heating are similar.
开发了使用微波辐射快速制备吗啡、安非他明和甲基安非他明的乙酰基、三氟乙酰基、五氟丙基、七氟丁基和N-甲基-N-（三甲基硅烷基）三氟乙酰胺衍生物的方法。传统的加热反应混合物的技术需要在60-70摄氏度下30分钟才能形成衍生物，但通过微波辐射，仅需2-3分钟。通过微波辐射和传统加热获得的衍生物的质谱碎裂模式和气相色谱保留时间相似。
