Dombi C, Bánóczy J, Kramer M, Wertz W P, Squier A C
Központi Stomatológiai Intézet, Budapest.
Fogorv Sz. 1999 May;92(5):137-42.
The significant increase in the mortality rates of oral carcinoma speeded up the research on the mechanisms of tumor promoting and inhibiting factors. Results of previous studies in the USA showed different permeability between keratinized (hard palate, gingive) and non-keratinized (floor of the mouth) regions of the oral mucosa, and a corresponding difference in lipid composition. Aim of this study was, to compare the permeability and lipid composition of leukoplakia of the oral mucosa with healthy specimens from the same region, in order to assess a possible enhancement or inhibition in the barrier-function, in cases of pathological keratinization. Results of the measurements showed, that hyperplastic leukoplakia areas were more permeable for the NNN carcinogens contained in tobacco, and even clinically healthy sites showed a higher permeability, that oral mucosa of non-smokers. These data together with the results of lipid analysis, point to the possible generalized changes--caused by smoking--in the oral cavity, even before the appearance of clinical signs.
口腔癌死亡率的显著上升加速了对肿瘤促进和抑制因素机制的研究。美国先前的研究结果表明，口腔黏膜的角化区域（硬腭、牙龈）和非角化区域（口腔底部）之间存在不同的通透性，并且脂质组成也存在相应差异。本研究的目的是比较口腔黏膜白斑与同一区域健康标本的通透性和脂质组成，以评估在病理性角化情况下屏障功能可能的增强或抑制。测量结果显示，增生性白斑区域对烟草中含有的NNN致癌物的通透性更高，甚至临床健康部位的通透性也高于非吸烟者的口腔黏膜。这些数据与脂质分析结果一起表明，即使在临床症状出现之前，吸烟也可能导致口腔出现普遍的变化。
