March L M, Chamberlain A C, Cameron I D, Cumming R G, Brnabic A J, Finnegan T P, Kurrle S E, Schwarz J M, Nade S M, Taylor T K
Northern Sydney Area Health Service Public Health Unit, Hornsby Ku-ring-gai Hospital, Sydney, NSW.
Med J Aust. 1999 May 17;170(10):489-94.
To develop evidence-based guidelines for the treatment of proximal femoral fractures to optimise functional outcome while minimising length of stay in hospital.
Systematic literature search of MEDLINE and CINAHL computer databases, bibliographies, and current contents of key journals for 1966-1995.
English-language randomised controlled trials of all aspects of acute-care hospital treatment of proximal femoral fracture among subjects aged 50 years and over with proximal femoral fractures not due to metastatic disease.
Two independent reviewers, blinded to authors, institution and study results, followed a standard Cochrane Collaboration protocol and assessed study quality and treatment conclusions. When necessary, a third review was performed to reach consensus.
Of the 120 articles published between 1966 and December 1995, 97 met the inclusion criteria. Fifteen clinical interventions were reviewed. Five were supported by National Health and Medical Research Council (NHMRC) level I evidence (prophylactic anticoagulants, prophylactic antibiotics, regional anaesthesia, pressure-relieving mattresses, and internal surgical fixation), two had no supporting randomised controlled trial evidence (time to surgery, time to mobilisation after surgery) and the remainder were classified as having Level II evidence. A review of current practice (1993-94) identified wide variability in these interventions across five acute-care hospitals in the Northern Sydney Area Health Service.
Randomised controlled trial evidence (NHMRC Levels I and II) exists for many, but not all, aspects of hip fracture treatment. There is a need for changes to be made to some aspects of practice in accordance with evidence-based guidelines.
制定基于证据的股骨近端骨折治疗指南,以优化功能结局并缩短住院时间。
对MEDLINE和CINAHL计算机数据库、参考文献以及1966 - 1995年主要期刊的当期目录进行系统文献检索。
针对50岁及以上非转移性疾病所致股骨近端骨折患者急性护理医院治疗各方面的英文随机对照试验。
两名独立评审员,对作者、机构和研究结果不知情,遵循标准的Cochrane协作组方案,评估研究质量和治疗结论。必要时,进行第三次评审以达成共识。
1966年至1995年12月发表的120篇文章中,97篇符合纳入标准。对15种临床干预措施进行了综述。5种有澳大利亚国家卫生与医学研究委员会(NHMRC)I级证据支持(预防性抗凝剂、预防性抗生素、区域麻醉、减压床垫和内固定手术),2种没有随机对照试验证据支持(手术时机、术后活动时机),其余被归类为有II级证据。对当前实践(1993 - 1994年)的综述发现,悉尼北部地区卫生服务中心的五家急性护理医院在这些干预措施上存在很大差异。
对于髋部骨折治疗的许多方面,但并非所有方面,都存在随机对照试验证据(NHMRC I级和II级)。需要根据基于证据的指南对某些实践方面进行改变。