利培酮引起的血浆去甲肾上腺素升高与慢性精神分裂症的症状改善无关。
Risperidone-induced increase of plasma norepinephrine is not correlated with symptom improvement in chronic schizophrenia.
作者信息
See R E, Fido A A, Maurice M, Ibrahim M M, Salama G M
机构信息
Department of Psychiatry, Faculty of Medicine, Kuwait University, Safat, Kuwait.
出版信息
Biol Psychiatry. 1999 Jun 15;45(12):1653-6. doi: 10.1016/s0006-3223(98)00199-1.
BACKGROUND
Previous studies have shown an increase in plasma levels of norepinephrine (NE) after clozapine treatment of schizophrenia. This effect has been suggested to relate to improvement in symptoms.
METHODS
To test whether other novel antipsychotic drugs have such an effect, the present experiment examined schizophrenic symptoms and plasma levels of NE before and after 5 weeks of treatment with risperidone or haloperidol.
RESULTS
Risperidone, but not haloperidol, significantly increased plasma NE; however, there was no correlation of this effect with clinical improvement on any symptom scale.
CONCLUSIONS
This finding suggests that risperidone shares similar properties with clozapine in enhancing peripheral NE, but that these changes in plasma NE may not be a consistent indicator of atypical antipsychotic drug efficacy.
背景
先前的研究表明，氯氮平治疗精神分裂症后血浆去甲肾上腺素（NE）水平会升高。有人认为这种效应与症状改善有关。
方法
为了测试其他新型抗精神病药物是否有此效应，本实验检测了使用利培酮或氟哌啶醇治疗5周前后精神分裂症症状及血浆NE水平。
结果
利培酮显著提高了血浆NE水平，而氟哌啶醇则无此作用；然而，这种效应与任何症状量表上的临床改善均无相关性。
结论
这一发现表明，利培酮在增强外周NE方面与氯氮平具有相似特性，但血浆NE的这些变化可能并非非典型抗精神病药物疗效的一致指标。
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