慢性精神分裂症患者血清脑源性神经营养因子（BDNF）、前体BDNF水平及血浆3-甲氧基-4-羟基苯乙二醇水平
Serum levels of brain-derived neurotrophic factor (BDNF), proBDNF and plasma 3-methoxy-4-hydroxyphenylglycol levels in chronic schizophrenia.
作者信息
Yoshimura Reiji, Hori Hikaru, Katsuki Asuka, Atake Kiyokazu, Nakamura Jun
机构信息
Department of Psychiatry, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka 8078555 Japan.
出版信息
Ann Gen Psychiatry. 2016 Jan 14;15:1. doi: 10.1186/s12991-015-0084-9. eCollection 2016.
BACKGROUND
We investigated the serum levels of brain-derived neurotrophic factor (BDNF), proBDNF and plasma 3-methoxy-4-hydroxyphenylglycol (MHPG) levels in patients with chronic schizophrenia.
METHODS
Sixty-eight patients who met the DSM-IV-TR criteria and had a chronic schizophrenia (CS) duration of ≥ 5 years were enrolled. Their serum brain-derived BDNF and proBDNF levels were measured by enzyme-linked immunosorbent assays, and their plasma MHPG levels were analyzed by high-performance liquid chromatography with electrochemical detection.
RESULTS
The plasma MHPG levels were significantly lower in the CS group (3.9 ± 1.8 ng/ml) compared to those in the group of 32 age- and sex-matched healthy controls (5.1 ± 2.4 ng/ml). The serum BDNF levels were significantly lower in the CS group (8.9 ± 4.8 ng/ml) compared to the control group (12.2.1 ± 6.8 ng/ml). No correlation was observed between plasma MHPG and BDNF in the CS group.
CONCLUSION
These results suggest that hypo-activity of noradrenergic neurons and decreased BDNF secretion exist in chronic schizophrenic patients.
背景
我们研究了慢性精神分裂症患者血清中脑源性神经营养因子（BDNF）、前体BDNF水平以及血浆3-甲氧基-4-羟基苯乙二醇（MHPG）水平。
方法
纳入68例符合DSM-IV-TR标准且慢性精神分裂症（CS）病程≥5年的患者。采用酶联免疫吸附测定法检测其血清脑源性BDNF和前体BDNF水平，并用高效液相色谱-电化学检测法分析其血浆MHPG水平。
结果
与32名年龄和性别匹配的健康对照者（5.1±2.4 ng/ml）相比，CS组血浆MHPG水平显著降低（3.9±1.8 ng/ml）。与对照组（12.2±6.8 ng/ml）相比，CS组血清BDNF水平显著降低（8.9±4.8 ng/ml）。CS组血浆MHPG与BDNF之间未观察到相关性。
结论
这些结果表明，慢性精神分裂症患者存在去甲肾上腺素能神经元活性低下和BDNF分泌减少的情况。
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