Flammer J, Haefliger I O, Orgül S, Resink T
Department of Ophthalmology, University of Basel, Switzerland.
J Glaucoma. 1999 Jun;8(3):212-9.
Both intraocular pressure (IOP) and vascular factors appear to play an important role in the pathogenesis of glaucomatous optic neuropathy (GON). Arteriosclerosis and its risk factors are of minor importance, whereas vasospastic syndrome clearly is associated with GON. A vascular endotheliopathy seems to be involved in the diathetic hyperresponsiveness to stimuli, such as coldness or emotional stress. This in turn leads to a compromised autoregulation, and thereby renders the eye more sensitive to IOP or to a decrease in blood pressure. A variation in ocular perfusion may lead to an increase in free oxygen radicals. This may finally lead to apoptosis.
眼压（IOP）和血管因素似乎在青光眼性视神经病变（GON）的发病机制中都起着重要作用。动脉硬化及其危险因素的重要性较小，而血管痉挛综合征显然与GON有关。血管内皮病变似乎参与了对寒冷或情绪应激等刺激的素质性高反应性。这进而导致自动调节功能受损，从而使眼睛对眼压或血压下降更加敏感。眼灌注的变化可能导致游离氧自由基增加。这最终可能导致细胞凋亡。
