Sayah Diane N, Descovich Denise, Costantino Santiago, Lesk Mark R
Maisonneuve-Rosemont Hospital Research Center, Montreal, Quebec H1T 2M4, Canada.
University of Houston College of Optometry, Houston, Texas, 77204.
Ophthalmol Sci. 2024 Jul 18;4(6):100576. doi: 10.1016/j.xops.2024.100576. eCollection 2024 Nov-Dec.
To assess the relationship between the pulsatile choroidal volume change (ΔV) and ocular rigidity (OR), an important biomechanical property of the eye.
This is a prospective cross-sectional study.
Two hundred seventeen participants (235 eyes) were included in this study. Of those, 18 eyes (18 participants) had exudative retinal disease, and 217 eyes (199 participants) had open-angle glaucoma (39.2%), suspect discs (12.4%), ocular hypertension (14.3%), or healthy eyes (34.1%).
Pulsatile choroidal volume change was measured using dynamic OCT, which detects the change in choroidal thickness during the cardiac cycle. Ocular rigidity was measured using an invasive procedure as well as using a validated optical method. Correlations between ΔV and OR were assessed in subjects with healthy eyes, eyes with glaucoma, or eyes with exudative retinal disease.
Ocular rigidity and pulsatile ocular volume change.
In 18 eyes where OR was obtained invasively and ΔV was obtained noninvasively, a significant correlation was found between ΔV and OR (r = -0.664, = 0.003). Similarly, a strong inverse correlation was found between the noninvasive measurements of both ΔV and OR (r = -0.748, < 0.001) in a large cohort and maintained its significance across diagnostic groups (a more compliant eye is associated with greater ΔV). No correlation was found between ΔV and age, blood pressure, intraocular pressure, axial length, or diagnosis ( ≥ 0.05). Mean ΔV was 7.3 ± 3.4 μL for all groups combined with a range of 3.0 to 20.8 μL.
These results suggest an association between the biomechanics of the corneoscleral shell and pulsatile ocular blood flow, which may indicate that a more rigid eye exerts more resistance to pulsatile choroidal expansion. This highlights the dynamic nature of both blood flow and biomechanics in the eye, as well as how they may interact, leading to a greater understanding of the pathophysiology of ocular disease.
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
评估搏动性脉络膜容积变化（ΔV）与眼硬度（OR）之间的关系，眼硬度是眼睛一项重要的生物力学特性。
这是一项前瞻性横断面研究。
本研究纳入了217名参与者（235只眼）。其中，18只眼（18名参与者）患有渗出性视网膜疾病，217只眼（199名参与者）患有开角型青光眼（39.2%）、可疑视盘（12.4%）、高眼压症（14.3%）或健康眼（34.1%）。
使用动态光学相干断层扫描（OCT）测量搏动性脉络膜容积变化，该方法可检测心动周期中脉络膜厚度的变化。使用侵入性方法以及经过验证的光学方法测量眼硬度。在健康眼、青光眼眼或渗出性视网膜疾病眼中评估ΔV与OR之间的相关性。
眼硬度和搏动性眼容积变化。
在18只通过侵入性方法获得OR且通过非侵入性方法获得ΔV的眼中，发现ΔV与OR之间存在显著相关性（r = -0.664，P = 0.003）。同样，在一个大型队列中，ΔV和OR的非侵入性测量值之间也发现了很强的负相关性（r = -0.748，P < 0.001），并且在各诊断组中均保持显著（眼顺应性越高，ΔV越大）。未发现ΔV与年龄、血压、眼压、眼轴长度或诊断之间存在相关性（P≥0.05）。所有组的平均ΔV为7.3±3.4μL，范围为3.0至20.8μL。
这些结果表明角膜巩膜壳的生物力学与搏动性眼血流之间存在关联，这可能表明眼球越硬，对搏动性脉络膜扩张的阻力就越大。这突出了眼内血流和生物力学的动态性质，以及它们之间可能的相互作用，有助于更深入地理解眼病的病理生理学。
本文末尾的脚注和披露中可能包含专有或商业披露信息。
