Lippmann W, Seethaler K, Borella L E, Pugsley T A
Digestion. 1978;18(1-2):35-44. doi: 10.1159/000198182.
Alrestatin sodium (AY-22,284-A) inhibited gastric acid secretion and decreased the volume of gastric juice produced in the pylorus-ligated rat when administered intraperitoneally or perorally. Pentagastrin-induced gastric acid output in the unanesthetized rat was antagonized. The pyloric ligation-induced ulcer formation in the rat was inhibited. Alrestatin sodium did not exhibit an anticholinergic profile. The drug did not block the norepinephrine neuronal uptake mechanism in rat brain or heart; it did not alter the endogenous norepinephrine concentration in the heart and decreased endogeneous brain norepinephrine concentration. Alrestatin sodium is an effective inhibitor of gastric acid secretion and ulcer formation in the rat.
阿雷司他汀钠（AY - 22,284 - A）腹腔注射或口服给药时，可抑制幽门结扎大鼠的胃酸分泌并减少胃液分泌量。可拮抗未麻醉大鼠中五肽胃泌素诱导的胃酸分泌。可抑制大鼠幽门结扎诱导的溃疡形成。阿雷司他汀钠不具有抗胆碱能特性。该药物不阻断大鼠脑或心脏中的去甲肾上腺素神经元摄取机制；它不改变心脏中的内源性去甲肾上腺素浓度，而降低脑内源性去甲肾上腺素浓度。阿雷司他汀钠是大鼠胃酸分泌和溃疡形成的有效抑制剂。
