Lippmann W, Kobric M
Horm Metab Res. 1978 Jul;10(4):280-2. doi: 10.1055/s-0028-1093414.
Alrestatin, a lens aldose reductase inhibitor, decreased i.v. arginine-induced glucagon levels and augmented arginine-stimulated insulin release in the ether anesthetized rat. Alrestatin may then be useful in the treatment of diabetes mellitus, due to its actions on insulin and glucagon, and its capacity to delay the onset of sugar-induced cataracts in the rat.
醛糖还原酶抑制剂醛雷司他定可降低静脉注射精氨酸诱导的醚麻醉大鼠胰高血糖素水平，并增强精氨酸刺激的胰岛素释放。醛雷司他定对胰岛素和胰高血糖素的作用，以及延缓大鼠糖诱导性白内障发生的能力，使其可能对糖尿病治疗有用。
