Katoh T, Kaneko S, Takasawa S, Nagata N, Inatomi H, Ikemura K, Itoh H, Matsumoto T, Kawamoto T, Bell D A
Department of Health Information Science, School of Health Sciences, University of Occupational and Environmental Health, Kitakyushu, Japan.
Pharmacogenetics. 1999 Apr;9(2):165-9.
The A/G polymorphism at nucleotide 313 in the glutathione S-transferase P1-1 (GSTP1) gene was examined in patients with different types of smoking-related cancers (oral, lung, gastric, colorectal and urothelial cancers) and healthy control individuals. This polymorphism results in an amino acid substitution from isoleucine to valine at residue 105, which reduces catalytic activity of the enzyme. In control individuals, 23.8% of individuals had GSTP1 AG or GG genotype. This rose to 37.3% [n = 83, odds ratio = 1.93 (1.05-3.58), P = 0.035] in oral cancer patients. No increase in the frequency of the GSTP1 AG or GG genotype was obtained in lung, gastric, colorectal or urothelial cancers in this Japanese population. After grouping by smoking status, no consistent difference was observed between smoking patients and corresponding control individuals for the frequency of the GSTP1 A/G polymorphism for any cancer. However, a moderate risk (odds ratio = 2.78; 95% confidence interval 1.06-7.51) was associated with this polymorphism in the non-smoking group of oral cancer patients. The results suggest the GSTP1 polymorphism at nucleotide 313 may be associated with susceptibility to oral squamous cell carcinoma in the Japanese population.
在患有不同类型吸烟相关癌症（口腔癌、肺癌、胃癌、结直肠癌和尿路上皮癌）的患者以及健康对照个体中，检测了谷胱甘肽S-转移酶P1-1（GSTP1）基因第313位核苷酸处的A/G多态性。这种多态性导致第105位残基处的异亮氨酸被缬氨酸取代，从而降低了该酶的催化活性。在对照个体中，23.8%的个体具有GSTP1 AG或GG基因型。在口腔癌患者中，这一比例上升至37.3%[n = 83，优势比 = 1.93（1.05 - 3.58），P = 0.035]。在该日本人群的肺癌、胃癌、结直肠癌或尿路上皮癌患者中，未观察到GSTP1 AG或GG基因型频率增加。按吸烟状况分组后，对于任何癌症，吸烟患者与相应对照个体在GSTP1 A/G多态性频率方面未观察到一致差异。然而，在非吸烟的口腔癌患者组中，这种多态性与中度风险相关（优势比 = 2.78；95%置信区间1.06 - 7.51）。结果表明，第313位核苷酸处的GSTP1多态性可能与日本人群口腔鳞状细胞癌的易感性相关。
