Ma Yanjuan, Wei Xiaoxia, Han Guangye, Xue Minghui, Li Guangyan, Li Yan
Emergency Department, The First Affiliated Hospital of Xinxiang Medical University, No. 88 Healthy Road, Weihui, Henan Province, 453100, China.
Tumour Biol. 2013 Jun;34(3):1737-42. doi: 10.1007/s13277-013-0711-5. Epub 2013 Mar 2.
Glutathione S-transferase P1 (GSTP1) is an important enzyme playing critical roles in the phase II detoxification pathway. There were many studies investigating the association between GSTP1 gene Ile105Val polymorphism and gastric cancer risk, but studies from East Asians reported inconsistent findings. We performed a meta-analysis to investigate the association in East Asians. Published literature from PubMed and Chinese Biomedical Literature databases were searched for eligible publications. Pooled odds ratios (ORs) with 95 % confidence intervals (95 %CIs) were calculated using random or fixed-effect model according the between-study heterogeneity. A total of 12 studies with 2,552 cases and 5,474 controls were finally included into the meta-analysis. Meta-analysis of those 12 studies showed that there was an obvious association between GSTP1 Ile105Val polymorphism and gastric cancer risk in East Asians under three genetic models (for valine vs. isoleucine, OR=1.32, 95 %CI 1.05-1.66, P=0.015; for ValVal vs. IleIle, OR=2.00, 95 %CI 1.34-2.98, P=0.001; for the recessive model, OR=1.96, 95 %CI 1.35-2.83, P<0.001). Sensitivity analysis by removing one study at a time suggested the pooled results were stable under the three genetic models above. There was no risk of publication bias. In conclusion, the meta-analysis suggests that there is a strong evidence for the association between GSTP1 Ile105Val polymorphism and increased risk of gastric cancer in East Asians and contributes to increased risk of gastric cancer in East Asians.
谷胱甘肽S-转移酶P1（GSTP1）是一种在Ⅱ期解毒途径中发挥关键作用的重要酶。有许多研究探讨了GSTP1基因Ile105Val多态性与胃癌风险之间的关联，但东亚地区的研究报告结果并不一致。我们进行了一项荟萃分析以研究东亚人群中的这种关联。通过检索PubMed和中国生物医学文献数据库中的已发表文献来寻找符合条件的出版物。根据研究间的异质性，使用随机或固定效应模型计算合并比值比（OR）及95%置信区间（95%CI）。最终共有12项研究（2552例病例和5474例对照）纳入荟萃分析。对这12项研究的荟萃分析表明，在三种遗传模型下，GSTP1 Ile105Val多态性与东亚人群的胃癌风险之间存在明显关联（缬氨酸与异亮氨酸相比，OR = 1.32，95%CI 1.05 - 1.66，P = 0.015；ValVal与IleIle相比，OR = 2.00，95%CI 1.34 - 2.98，P = 0.001；隐性模型下，OR = 1.96，95%CI 1.35 - 2.83，P < 0.001）。每次去除一项研究的敏感性分析表明，在上述三种遗传模型下合并结果是稳定的。不存在发表偏倚风险。总之，荟萃分析表明，有强有力的证据支持GSTP1 Ile105Val多态性与东亚人群胃癌风险增加之间存在关联，且该多态性会增加东亚人群患胃癌的风险。
