Frank N, Sojka J E, Latour M A, McClure S R, Polazzi L
Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, IN 47907, USA.
Am J Vet Res. 1999 Jun;60(6):730-3.
To measure and compare concentrations of selected blood lipids before and after thyroidectomy in horses.
5 healthy adult mares.
Mares were confirmed to be euthyroid. Thyroidectomy was performed, and hypothyroidism was confirmed. Selected blood lipid variables were measured before hypothyroidism was induced and weekly for 4 weeks after induction. Plasma concentrations of very low-density lipoprotein (VLDL), low-density lipoprotein (LDL), serum triglyceride (TG), total cholesterol (TC), and nonesterified fatty acid (NEFA) were measured. The composition of VLDL and LDL also was examined.
Mean plasma concentrations of VLDL and LDL increased significantly after thyroidectomy. By 4 weeks after thyroidectomy, a ninefold increase in mean plasma concentration of VLDL and a threefold increase in LDL, compared with baseline values, were detected. After thyroidectomy, mean percentage of TG in VLDL increased significantly, whereas free cholesterol and cholesterol ester content decreased. Mean percentage of TG in LDL also increased by 3 to 4 weeks after thyroidectomy. Serum concentrations of TG and TC increased, whereas serum NEFA concentration decreased.
Hypothyroidism significantly alters blood lipid concentrations of horses. After thyroidectomy, markedly high VLDL concentration, appearance of TG-rich VLDL, increased serum concentrations of TG and TC, and decreased blood concentration of NEFA were evident.
Examination of blood lipid concentrations of horses may be useful for detecting naturally acquired hypothyroidism.
测量并比较马甲状腺切除术前和术后特定血脂的浓度。
5匹健康成年母马。
确认母马甲状腺功能正常。实施甲状腺切除术，并确认出现甲状腺功能减退。在诱发甲状腺功能减退之前以及诱发后4周内每周测量特定血脂变量。测量极低密度脂蛋白（VLDL）、低密度脂蛋白（LDL）、血清甘油三酯（TG）、总胆固醇（TC）和非酯化脂肪酸（NEFA）的血浆浓度。还检查了VLDL和LDL的组成。
甲状腺切除术后，VLDL和LDL的平均血浆浓度显著升高。与基线值相比，甲状腺切除术后4周时，VLDL的平均血浆浓度增加了9倍，LDL增加了3倍。甲状腺切除术后，VLDL中TG的平均百分比显著增加，而游离胆固醇和胆固醇酯含量降低。甲状腺切除术后3至4周，LDL中TG的平均百分比也增加。血清TG和TC浓度升高，而血清NEFA浓度降低。
甲状腺功能减退显著改变马的血脂浓度。甲状腺切除术后，明显出现高浓度的VLDL、富含TG的VLDL、血清TG和TC浓度升高以及血液NEFA浓度降低。
检测马的血脂浓度可能有助于发现自然发生的甲状腺功能减退。
