Venables J P, Eperon I
Department of Biochemistry University of Leicester University Road, Leicester, LE1 7RH, UK.
Curr Opin Genet Dev. 1999 Jun;9(3):346-54. doi: 10.1016/s0959-437x(99)80052-5.
RNA-binding proteins are essential for spermatogenesis: they are required in the nucleus of germ cells, for the production of specific mRNA isoforms, and in the cytoplasm - where proteins required for chromatin condensation and for changes in cell morphology are translated long after transcription ceases. Some of the RNA targets and the RNA-binding proteins themselves have been identified recently. Both nuclear and cytoplasmic proteins are affected in examples of azoospermia in men.
RNA结合蛋白对精子发生至关重要：它们在生殖细胞的细胞核中是产生特定mRNA异构体所必需的，在细胞质中也是必需的——在转录停止很久之后，染色质浓缩和细胞形态变化所需的蛋白质在这里进行翻译。最近已经鉴定出了一些RNA靶点以及RNA结合蛋白本身。在男性无精子症的例子中，细胞核和细胞质蛋白都会受到影响。
