Weir F J, Ohlsson A, Myhr T L, Fong K, Ryan M L
Department of Newborn and Developmental Paediatrics, Women's College Hospital, Toronto, Ontario, Canada.
Eur J Pediatr. 1999 Jun;158(6):484-7. doi: 10.1007/s004310051125.
The study objective was to determine the effect of a patent ductus arteriosus (PDA) on cerebral blood flow velocity in ventilated, very low birth weight neonates, in the first 5 days of life. Sonography of the right middle cerebral artery and ductus arteriosus was performed using a colour Doppler technique. Statistical analysis was by stepwise regression. Thirty-one neonates without and 43 with a PDA, mean (SD) birth weight 1004 g +/- 192 and 1071 g +/- 227 respectively, were studied. The end diastolic and mean velocities were reduced (P = 0.008 and P = 0.129) and the resistive index was increased (P = 0.047) by a PDA. pH was inversely related to end diastolic and mean velocities (P = 0.015 and P = 0.003), suggesting that low pH may increase cerebral artery blood flow velocity.
A patent ductus arteriosus reduces middle cerebral artery blood flow velocity in very low birth weight neonates.
本研究目的是确定出生后5天内，动脉导管未闭（PDA）对机械通气的极低出生体重儿脑血流速度的影响。采用彩色多普勒技术对右侧大脑中动脉和动脉导管进行超声检查。采用逐步回归进行统计分析。研究了31例无PDA的新生儿和43例有PDA的新生儿，平均（标准差）出生体重分别为1004 g±192 g和1071 g±227 g。PDA使舒张末期和平均速度降低（P = 0.008和P = 0.129），阻力指数升高（P = 0.047）。pH与舒张末期和平均速度呈负相关（P = 0.015和P = 0.003），提示低pH可能增加脑动脉血流速度。
动脉导管未闭降低极低出生体重儿大脑中动脉血流速度。
