Cook A M, Patterson H, Nicholls J, Huddart R A
Royal Marsden Hospital, Sutton, UK.
Clin Oncol (R Coll Radiol). 1999;11(2):126-7. doi: 10.1053/clon.1999.9027.
Avascular necrosis (AVN) is known to occur after combination chemotherapy for lymphomas and leukaemias that includes high dose corticosteroids, but it has been reported rarely in patients with solid tumours. We describe five recent cases in young men with testicular tumours (three of which were of good prognosis), who had been treated with chemotherapy using dexamethasone as an antiemetic. Dexamethasone is a low cost and effective antiemetic, but it may be responsible for inducing AVN in patients receiving chemotherapy for solid tumours. A prospective survey of the frequency of AVN is justified to quantify the extent of the problem.
已知在包括高剂量皮质类固醇的淋巴瘤和白血病联合化疗后会发生无血管性坏死（AVN），但在实体瘤患者中鲜有报道。我们描述了5例近期患有睾丸肿瘤的年轻男性病例（其中3例预后良好），他们接受了以地塞米松作为止吐药的化疗。地塞米松是一种低成本且有效的止吐药，但它可能是接受实体瘤化疗患者发生AVN的原因。对AVN发生频率进行前瞻性调查是合理的，以便量化该问题的严重程度。
