Obaya A J, Mateyak M K, Sedivy J M
Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island 02912, USA.
Oncogene. 1999 May 13;18(19):2934-41. doi: 10.1038/sj.onc.1202749.
A large body of physiological evidence shows that either upregulation or downregulation of intracellular c-Myc activity has profound consequences on cell cycle progression. Recent work suggests that c-Myc may stimulate the activity of cyclin E/cyclin-dependent kinase 2 (Cdk2) complexes and antagonize the action of the Cdk inhibitor p27KIP1. Cyclin D/Cdk4/6 complexes have also been implicated as targets of c-Myc activity. However, in spite of considerable effort, the mechanisms by which c-Myc interacts with the intrinsic cyclin/Cdk cell cycle machinery remain undefined.
大量生理学证据表明，细胞内c-Myc活性的上调或下调都会对细胞周期进程产生深远影响。最近的研究表明，c-Myc可能会刺激细胞周期蛋白E/细胞周期蛋白依赖性激酶2（Cdk2）复合物的活性，并拮抗细胞周期蛋白依赖性激酶抑制剂p27KIP1的作用。细胞周期蛋白D/Cdk4/6复合物也被认为是c-Myc活性的靶点。然而，尽管进行了大量研究，c-Myc与内在的细胞周期蛋白/Cdk细胞周期机制相互作用的机制仍不明确。
