人类B细胞群体中的CD5表达。

CD5 expression in human B-cell populations.

作者信息

Youinou P, Jamin C, Lydyard P M

机构信息

Laboratory of Immunology, Institut de Synergie des Sciences et de la Santé, Brest University Medical School Hospital, BP 824, F-29609 Brest Cedex, France.

出版信息

Immunol Today. 1999 Jul;20(7):312-6. doi: 10.1016/s0167-5699(99)01476-0.

DOI:10.1016/s0167-5699(99)01476-0

PMID:10379049

Abstract

The origin of CD5+ B cells remains controversial. The differential response to ligation of CD5 resulting in apoptosis or proliferation provides insight into its roles in distinct human B cells. Here, Pierre Youinou, Christophe Jamin and Peter Lydyard review current knowledge of B-1 and B-2 cells, and propose that CD5 has different functions when expressed by different B-cell subpopulations.

摘要

CD5+ B细胞的起源仍存在争议。CD5连接后导致细胞凋亡或增殖的不同反应，为其在不同人类B细胞中的作用提供了见解。在此，皮埃尔·尤伊努、克里斯托夫·贾曼和彼得·利德亚德回顾了关于B-1和B-2细胞的现有知识，并提出CD5在不同B细胞亚群中表达时具有不同功能。