类风湿关节炎和干燥综合征中T和B细胞亚群上CD5和CD72的表达。
Expression of CD5 and CD72 on T and B cell subsets in rheumatoid arthritis and Sjögren's syndrome.
作者信息
Jamin C, Lamour A, Pennec Y L, Hirn M, Le Goff P, Youinou P
机构信息
Laboratory of Immunology, Brest University Medical School Hospital, France.
出版信息
Clin Exp Immunol. 1993 May;92(2):245-50. doi: 10.1111/j.1365-2249.1993.tb03387.x.
A minority of B cells express the CD5 marker, which is found on virtually all T cells, and CD72 has been defined as the CD5 ligand on the B cell membrane. The mean fluorescence intensity (MFI) of the CD5 molecules was shown to be higher on CD4+CD29+ than CD4+CD45RA+ in peripheral blood (PB) and synovial fluid (SF) of rheumatoid arthritis (RA) patients (P < 0.0001 and < 0.001), and PB of Sjögren's syndrome (SS) patients and normal controls (P < 0.02 and < 0.03). This MFI declined once the CD4 expressed HLA-DR in PB of SS patients (P < 0.004) and normal controls (P < 0.02) or CD25 in PB of RA (P < 0.004) and SS patients (P < 0.0004). There was a correlation between the CD5 MFI on CD4+CD45RA+ and CD4+CD29+ in RA (P < 0.001) as well as SS (P < 0.0007) PB. The CD72 MFI was impressively higher on CD5+ than CD5- B cells in PB and SF of RA patients (P < 0.0001 and P < 0.005) and PB of SS patients (P < 0.005) and normal controls (P < 0.005). Our data suggest that, in association with CD4CD29, CD5 is involved in CD5+B/CD5+ B cell interactions in non-organ-specific autoimmune diseases.
少数B细胞表达CD5标志物，该标志物几乎存在于所有T细胞上，而CD72已被定义为B细胞膜上的CD5配体。在类风湿性关节炎（RA）患者的外周血（PB）和滑液（SF）中，CD4 + CD29 +细胞上CD5分子的平均荧光强度（MFI）高于CD4 + CD45RA +细胞（P < 0.0001和< 0.001），在干燥综合征（SS）患者的PB以及正常对照中也是如此（P < 0.02和< 0.03）。一旦SS患者PB中的CD4表达HLA - DR（P < 0.004）和正常对照（P < 0.02），或者RA患者PB（P < 0.004）和SS患者PB（P < 0.0004）中的CD4表达CD25，这种MFI就会下降。在RA（P < 0.001）以及SS（P < 0.0007）患者的PB中，CD4 + CD45RA +和CD4 + CD29 +细胞上的CD5 MFI之间存在相关性。在RA患者的PB和SF中（P < 0.0001和P < 0.005）、SS患者的PB（P < 0.005）以及正常对照（P < 0.005）中，CD5 + B细胞上的CD72 MFI显著高于CD5 - B细胞。我们的数据表明，与CD4CD29相关，CD5参与非器官特异性自身免疫疾病中CD5 + B/CD5 + B细胞的相互作用。
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