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对头颈部进行放射治疗的孕妇的技术管理。

Technical management of a pregnant patient undergoing radiation therapy to the head and neck.

作者信息

Podgorsak M B, Meiler R J, Kowal H, Kishel S P, Orner J B

机构信息

Department of Radiation Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

出版信息

Med Dosim. 1999 Summer;24(2):121-8. doi: 10.1016/s0958-3947(99)00010-2.

Abstract

The fetal dose in a pregnant patient undergoing radiation therapy to the head and neck region was investigated. Implicit in this study was the design and evaluation of a shield used to minimize the fetal dose. To evaluate the fetal dose, a phantom was irradiated with the fields designed for this patient's therapy. The peripheral dose was measured for each field individually, both without and with a custom shield designed to be placed about the patient's abdominal and pelvic regions. The total dose at the location of the fetus over the course of this patient's radiation therapy was then estimated from peripheral dose rate measurements made at several points within the simulated uterus. With no shielding, the total dose within the uterus of the patient would have ranged from 13.3 cGy at the cervix to 28 cGy at the fundus. With the shield applied, the uterine dose was significantly less: 3.3 cGy at the cervix to 8.6 cGy at the fundus. In fact, at every measurement point, the peripheral dose with the shield in place was 30% to 50% of the dose without the shield. Some data suggest that the rate of significant abnormalities induced by irradiation in utero increases with increasing dose within the range of total peripheral doses incurred during most radiation treatment courses. It is therefore prudent to make reasonable attempts at minimizing the dose to the lower abdominal and pelvic regions of any pregnant patient. The shield designed in this work accomplished this goal for this patient and is flexible enough to be used in the treatment of almost all tumor volumes.

摘要

对一名接受头颈部放射治疗的孕妇的胎儿剂量进行了研究。本研究的一个隐含内容是设计和评估一种用于使胎儿剂量最小化的防护装置。为了评估胎儿剂量,用为该患者治疗设计的射野对一个体模进行照射。分别测量每个射野在无防护装置以及使用定制防护装置(设计用于放置在患者腹部和盆腔区域)时的周边剂量。然后根据在模拟子宫内几个点进行的周边剂量率测量,估算该患者放射治疗过程中胎儿位置处的总剂量。在无防护的情况下,患者子宫内的总剂量范围为宫颈处13.3 cGy至宫底处28 cGy。使用防护装置后,子宫剂量显著降低:宫颈处为3.3 cGy,宫底处为8.6 cGy。事实上,在每个测量点,使用防护装置时的周边剂量是不使用防护装置时剂量的30%至50%。一些数据表明,在子宫内受照射诱发显著异常的发生率会随着在大多数放射治疗疗程中所产生的总周边剂量范围内剂量的增加而上升。因此,对于任何孕妇,合理尝试将其下腹部和盆腔区域的剂量最小化是谨慎之举。本研究设计的防护装置为该患者实现了这一目标,并且足够灵活,可用于几乎所有肿瘤体积的治疗。

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