Lynne C M, Aballa T C, Wang T J, Rittenhouse H G, Ferrell S M, Brackett N L
Department of Urology and The Miami Project to Cure Paralysis, University of Miami School of Medicine, Florida, USA.
J Urol. 1999 Jul;162(1):89-91. doi: 10.1097/00005392-199907000-00022.
Recent investigations have indicated that factors within the seminal plasma may contribute to the condition of low sperm motility in men with spinal cord injury. To determine whether the prostate gland functions normally in these men we chose prostate specific antigen (PSA) as a marker of prostatic function, and compared serum and semen concentrations in spinal cord injured and healthy noninjured men.
The study included 21 spinal cord injured men (mean age 33.3+/-1.2 years) and 22 noninjured normal men (mean age 30.3+/-1.5 years). Blood was obtained from subjects following at least 24 hours of abstinence from ejaculation and serum PSA was determined by modified enzyme immunoassay. Antegrade ejaculates from all subjects were frozen to -80 C, exactly 15 minutes after collection. Seminal plasma PSA was determined using Hybritech Tandem MP assay.
Mean serum PSA concentration was 1.20+/-0.19 ng./ml. in spinal cord injured and 0.69+/-0.07 ng./ml. in noninjured men (p<0.02). Mean seminal plasma PSA concentration was 0.59+/-0.11 mg./ml. in spinal cord injured and 1.29+/-0.15 mg./ml. in noninjured men (p<0.001).
Our findings of elevated serum and decreased seminal plasma PSA concentrations indicate that prostatic secretory dysfunction is present in men with spinal cord injury.
近期研究表明，精浆中的因素可能导致脊髓损伤男性精子活力低下。为了确定这些男性的前列腺功能是否正常，我们选择前列腺特异性抗原（PSA）作为前列腺功能的标志物，并比较了脊髓损伤男性和健康未受伤男性的血清和精液中PSA的浓度。
该研究纳入了21名脊髓损伤男性（平均年龄33.3±1.2岁）和22名未受伤的正常男性（平均年龄30.3±1.5岁）。在受试者至少禁欲24小时后采集血液，采用改良酶免疫测定法测定血清PSA。所有受试者的顺行射精样本在采集后15分钟立即冷冻至-80℃。使用Hybritech Tandem MP测定法测定精浆PSA。
脊髓损伤男性的平均血清PSA浓度为1.20±0.19 ng./ml，未受伤男性为0.69±0.07 ng./ml（p<0.02）。脊髓损伤男性的平均精浆PSA浓度为0.59±0.11 mg./ml，未受伤男性为1.29±0.15 mg./ml（p<0.001）。
我们发现脊髓损伤男性血清PSA升高而精浆PSA降低，这表明他们存在前列腺分泌功能障碍。
