Weitkamp L R, Ober C
Department of Psychiatry, University of Rochester Medical Center, NY 14642, USA.
Immunogenetics. 1999 Jun;49(6):491-7. doi: 10.1007/s002510050525.
Prior studies in the Schmiedeleut Hutterites of South Dakota have demonstrated associations between human leukocyte antigen (HLA) haplotype matching and fetal loss (Ober et al. 1992) and mate preferences (Ober et al. 1997), as well as deficiencies of homozygotes for HLA haplotypes (Kostyu et al. 1993). These studies were based on the serologically-defined five-locus HLA-A, -C, -B, -DR, -DQ haplotype. To further elucidate the effects of specific major histocompatibility (MHC) loci or regions on fetal loss and mate choice, we genotyped a sample of Hutterites for 14 MHC loci by DNA or biochemical methods. Typing for additional loci in the HLA-A to HLA-DPB1 region increased the number of recognized Hutterite MHC haplotypes to 67, and further localized the site of crossover in 9 of 15 recombinant haplotypes. Hutterite MHC haplotype sequences are similar to those observed in outbred Caucasians, suggesting that the influence of HLA haplotypes on fetal loss and mating structure may be general.
此前对南达科他州施米德莱特哈特派的研究已证明，人类白细胞抗原（HLA）单倍型匹配与胎儿丢失（奥伯等人，1992年）、配偶偏好（奥伯等人，1997年）以及HLA单倍型纯合子缺陷（科斯蒂尤等人，1993年）之间存在关联。这些研究基于血清学定义的五位点HLA - A、- C、- B、- DR、- DQ单倍型。为了进一步阐明特定主要组织相容性（MHC）位点或区域对胎儿丢失和配偶选择的影响，我们通过DNA或生化方法对哈特派的一个样本进行了14个MHC位点的基因分型。对HLA - A至HLA - DPB1区域的其他位点进行分型后，已识别的哈特派MHC单倍型数量增加到67种，并进一步确定了15种重组单倍型中9种的交叉位点。哈特派MHC单倍型序列与非近亲繁殖的高加索人中观察到的序列相似，这表明HLA单倍型对胎儿丢失和交配结构的影响可能具有普遍性。
