Ober C
Department of Human Genetics, University of Chicago, IL 60615, USA.
Hum Reprod Update. 1999 Mar-Apr;5(2):103-7. doi: 10.1093/humupd/5.2.103.
The role of human leukocyte antigen (HLA) genes in pregnancy and in human mate choice has been investigated in the Hutterites, an inbred population of European origins. High-resolution HLA haplotypes were defined by alleles at 16 loci in >1000 Hutterites. Prospective studies of pregnancy outcome previously demonstrated increased fetal loss rates among Hutterite couples matching for HLA-B antigens (P = 0.033) or for the entire 16-locus haplotype (P = 0.002). Among living children of couples matching for HLA-B or for the haplotype, there was a non-significant deficit of children who were heterozygous and compatible with the mother; the number of living children who were compatible and homozygous or incompatible and heterozygous was not different than expectations (HLA-B, P = 0.095; haplotype, P = 0.376). Mate choice among 411 couples was non-random with respect to the HLA haplotype, assessed by a variety of methods (P = 0.020 to <0.001). These combined data indicate a role for HLA region genes in both pregnancy outcome and mate choice, and suggest that selection acting on these genes occurs pre-conceptually as well as during pregnancy. This review outlines previously published studies on HLA, fertility and mate choice in the Hutterites.
人类白细胞抗原（HLA）基因在妊娠及人类配偶选择中的作用已在哈特派中展开研究，哈特派是一个起源于欧洲的近亲群体。通过对1000多名哈特派个体的16个基因座的等位基因定义了高分辨率HLA单倍型。先前对妊娠结局的前瞻性研究表明，HLA - B抗原匹配（P = 0.033）或16个基因座单倍型完全匹配（P = 0.002）的哈特派夫妇中胎儿丢失率增加。在HLA - B或单倍型匹配的夫妇的存活子女中，与母亲杂合且相容的子女数量有不显著的不足；存活的相容且纯合或不相容且杂合的子女数量与预期无差异（HLA - B，P = 0.095；单倍型，P = 0.376）。通过多种方法评估，411对夫妇之间的配偶选择在HLA单倍型方面并非随机（P = 从0.020至<0.001）。这些综合数据表明HLA区域基因在妊娠结局和配偶选择中均发挥作用，并表明作用于这些基因的选择在受孕前以及孕期均会发生。本综述概述了先前发表的关于哈特派中HLA、生育力和配偶选择的研究。
