Kita H, Tokuno H, Nambu A
Department of Anatomy and Neurobiology, College of Medicine, University of Tennessee Memphis, 38163, USA.
Neuroreport. 1999 May 14;10(7):1467-72. doi: 10.1097/00001756-199905140-00014.
Experiments were performed to assess the number and parvalbumin (PV) immunoreactivity of neurons participating in the pallidostriatal projection in macaque monkeys. Injection of WGA-HRP into the right caudate nucleus and the left putamen of a Macaca mulatta and a M. fuscata labeled a large number of the globus pallidus external segment (GPe) neurons. Counting neurons labeled with WGA-HRP and those stained with neuronal markers indicated that approximately 30% of GPe neurons project to neostriatum. Approximately 2/3 of the pallidostriatal neurons are PV-immunoreactive. This study revealed that a significant number of primate GPe PV immunoreactive neurons project to the neostriatum, and suggest that the pallidostriatal projection should be taken into account in the analysis of functional roles of the basal ganglia circuitry.
进行实验以评估参与猕猴苍白球-纹状体投射的神经元数量和小白蛋白（PV）免疫反应性。将WGA-HRP注射到一只恒河猴和一只食蟹猴的右侧尾状核和左侧壳核中，标记了大量苍白球外侧段（GPe）神经元。对用WGA-HRP标记的神经元和用神经元标志物染色的神经元进行计数表明，约30%的GPe神经元投射到新纹状体。约2/3的苍白球-纹状体神经元具有PV免疫反应性。本研究表明，大量灵长类动物GPe PV免疫反应性神经元投射到新纹状体，并提示在分析基底神经节回路的功能作用时应考虑苍白球-纹状体投射。
