Petersen K L, Rowbotham M C
Department of Neurology, UCSF Pain Clinical Research Center, University of California, San Francisco 94115, USA.
Neuroreport. 1999 May 14;10(7):1511-6. doi: 10.1097/00001756-199905140-00022.
The heat/capsaicin sensitization model is a new human experimental pain model that synergistically combines non-invasive physical and chemical methods of nociceptor stimulation to produce stable and long-lasting hyperalgesia with a low potential for skin injury. In 10 healthy volunteers the forearm was stimulated with a 45 degrees C thermode for 5 min to produce an area of secondary hyperalgesia. Applying capsaicin cream for 30 min further expanded the area of secondary hyperalgesia. Periodically heating the treated skin with a previously non-painful temperature of 40 degrees C re-kindled the sensitization enough to maintain stable areas of secondary hyperalgesia for 4h. The evoked pain was moderate and well tolerated. The heat/capsaicin sensitization model should be well suited for studying pain mechanisms and testing new analgesics.
热/辣椒素致敏模型是一种新的人体实验性疼痛模型，它将伤害感受器刺激的非侵入性物理和化学方法协同结合，以产生稳定且持久的痛觉过敏，同时皮肤损伤可能性低。在10名健康志愿者中，用45摄氏度的热刺激器刺激前臂5分钟，以产生继发性痛觉过敏区域。涂抹辣椒素乳膏30分钟可进一步扩大继发性痛觉过敏区域。用先前无疼痛的40摄氏度温度定期加热处理过的皮肤，可充分重新激发致敏作用，从而使继发性痛觉过敏区域稳定维持4小时。诱发的疼痛程度适中且耐受性良好。热/辣椒素致敏模型应非常适合研究疼痛机制和测试新的镇痛药。
