Dirks Jesper, Petersen Karin L, Dahl Jørgen B
Laboratory of Pain Physiology, Multidisciplinary Pain Center, Herlev University Hospital, Herlev, Denmark.
J Pain. 2003 Apr;4(3):122-8. doi: 10.1054/jpai.2003.10.
The heat/capsaicin sensitization model induces cutaneous sensitization by using a combination of heat and topical capsaicin. It has been suggested that the stability and duration of the cutaneous sensitization are due to a synergistic effect between heat and capsaicin. The aim of this study was to evaluate a possible synergistic effect between heat and capsaicin in inducing cutaneous sensitization. Twenty healthy male volunteers completed this random order, 4-session study. Three different stimulation combinations were used to induce cutaneous sensitization: day A, heat and capsaicin; day B, heat alone; day C, capsaicin alone. Combination A was repeated on day D to determine between day reproducibility. Rekindling was performed 3 times at 40-minute intervals to maintain stable areas of secondary hyperalgesia. Brief thermal sensitization (45 degrees C for 3 minutes) was induced at each session. Within and between day reproducibility was calculated. There was no difference between the size of areas of secondary hyperalgesia after stimulation with heat/capsaicin compared to heat and capsaicin stimulation alone. The within day reproducibility was better with heat/capsaicin than with either stimulation alone. There was no synergistic or additive effect between heat and capsaicin in inducing cutaneous sensitization. Rekindling seems to be the important factor in maintaining stable and long-lasting cutaneous sensitization.
热/辣椒素致敏模型通过联合使用热刺激和局部辣椒素来诱导皮肤致敏。有人认为，皮肤致敏的稳定性和持续时间归因于热和辣椒素之间的协同作用。本研究的目的是评估热和辣椒素在诱导皮肤致敏过程中可能存在的协同作用。20名健康男性志愿者完成了这项随机顺序、分4阶段的研究。使用三种不同的刺激组合来诱导皮肤致敏：A日，热刺激和辣椒素；B日，仅热刺激；C日，仅辣椒素刺激。D日重复A组合以确定日间重复性。每隔40分钟进行3次再激发以维持继发性痛觉过敏的稳定区域。每次试验均诱导短暂的热致敏（45℃，持续3分钟）。计算日内和日间重复性。与单独的热刺激和辣椒素刺激相比，热/辣椒素刺激后继发性痛觉过敏区域的大小没有差异。热/辣椒素刺激的日内重复性优于单独的任何一种刺激。热和辣椒素在诱导皮肤致敏方面不存在协同或相加效应。再激发似乎是维持稳定且持久的皮肤致敏的重要因素。
