1,25-二羟维生素D3受体免疫反应性在大鼠嗅觉系统中的分布。
Distribution of 1,25-dihydroxyvitamin D3 receptor immunoreactivity in the rat olfactory system.
作者信息
Glaser S D, Veenstra T D, Jirikowski G F, Prüfer K
机构信息
Institut für Anatomie II, Friedrich-Schiller Universität Jena, Germany.
出版信息
Cell Mol Neurobiol. 1999 Oct;19(5):613-24. doi: 10.1023/a:1006932418220.
Abstract
- The rat olfactory system contains numerous target sites for 1,25-dihydroxyvitamin D3, as determined by receptor protein (VDR) immunocytochemistry and in situ hybridization. 2. Nuclear and cytoplasmic VDR immunoreactivity as well as the corresponding hybridization signal was observed in neurons in the olfactory epithelium, the olfactory bulb, and throughout the limbic system in locations also known to be glucocorticoid targets. 3. The widespread distribution of VDR indicates the distinct functional importance of 1,25-dihydroxyvitamin D3 for olfactory perception.
摘要
- 通过受体蛋白（VDR）免疫细胞化学和原位杂交确定，大鼠嗅觉系统含有众多1,25 - 二羟基维生素D3的靶位点。2. 在嗅觉上皮、嗅球以及整个边缘系统中已知也是糖皮质激素靶标的位置的神经元中，观察到了核和细胞质VDR免疫反应性以及相应的杂交信号。3. VDR的广泛分布表明1,25 - 二羟基维生素D3对嗅觉感知具有独特的功能重要性。
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