Friedrich R W, Korsching S I
Max-Planck-Institut für Entwicklungsbiologie, Abteilung Physikalische Biologie, Tübingen, Federal Republic of Germany.
Neuron. 1997 May;18(5):737-52. doi: 10.1016/s0896-6273(00)80314-1.
Odors are thought to be represented by a distributed code across the glomerular modules in the olfactory bulb (OB). Here, we optically imaged presynaptic activity in glomerular modules of the zebrafish OB induced by a class of natural odorants (amino acids [AAs]) after labeling of primary afferents with a calcium-sensitive dye. AAs induce complex combinatorial patterns of active glomerular modules that are unique for different stimuli and concentrations. Quantitative analysis shows that defined molecular features of stimuli are correlated with activity in spatially confined groups of glomerular modules. These results provide direct evidence that identity and concentration of odorants are encoded by glomerular activity patterns and reveal a coarse chemotopic organization of the array of glomerular modules.
气味被认为是通过嗅球（OB）中肾小球模块的分布式编码来呈现的。在这里，我们在用钙敏染料标记初级传入神经后，对一类天然气味剂（氨基酸 [AAs]）诱导的斑马鱼OB肾小球模块中的突触前活动进行了光学成像。氨基酸诱导活跃肾小球模块的复杂组合模式，这些模式对于不同的刺激和浓度是独特的。定量分析表明，刺激的特定分子特征与肾小球模块空间受限组中的活动相关。这些结果提供了直接证据，表明气味剂的身份和浓度由肾小球活动模式编码，并揭示了肾小球模块阵列的粗略化学拓扑组织。
