Hustinx R, Paulus P, Daenen F, Detroz B, Honoré P, Jacquet N, Rigo P
Service de Médecine Nucléaire, Centre Hospitalier Universitaire de Liège, Belgique.
Gastroenterol Clin Biol. 1999 Mar;23(3):323-9.
Positron emission tomography (PET) has been shown useful for the staging of patients with various carcinomas.
We have applied this technique to 54 cases of colorectal carcinoma and compared it to conventional imaging techniques.
PET had moderately higher sensitivity and specificity than conventional techniques to detect individual lesion sites (75% vs 70.8% and 63% vs 21% respectively). It detected the same number of patients with recurrences (35/39) but overestimated disease less frequently (5 cases vs 12). PET favorably influenced therapeutic management in 17 patients, indicating different or additional surgery in 9 while avoiding surgery with curative intent or unnecessary surgery in 8. In 5 cases, erroneous information provided by PET could be corrected by conventional imaging techniques.
We conclude that PET appears to provide complementary information useful for staging patients with colorectal carcinomas. It can significantly modify patients management. These data should be confirmed by a prospective study.
正电子发射断层扫描（PET）已被证明对各种癌症患者的分期有用。
我们将该技术应用于54例结直肠癌患者，并与传统成像技术进行比较。
在检测单个病变部位时，PET的敏感性和特异性略高于传统技术（分别为75%对70.8%和63%对21%）。它检测到复发患者的数量相同（35/39），但高估疾病的频率较低（5例对12例）。PET对17例患者的治疗管理产生了有利影响，其中9例表明需要进行不同或额外的手术，而8例避免了根治性手术或不必要的手术。在5例病例中，PET提供的错误信息可通过传统成像技术纠正。
我们得出结论，PET似乎能提供有助于结直肠癌患者分期的补充信息。它可显著改变患者的治疗管理。这些数据应通过前瞻性研究加以证实。
