Falk P M, Gupta N C, Thorson A G, Frick M P, Boman B M, Christensen M A, Blatchford G J
Section of Colon and Rectal Surgery, Creighton University School of Medicine, Omaha, Nebraska 68131.
Dis Colon Rectum. 1994 Feb;37(2):153-6. doi: 10.1007/BF02047538.
Positron emission tomography (PET) is an imaging technique based on in vivo cellular metabolism. Increased glucose metabolism in neoplastic cells is detected by using fluorine-18 deoxyglucose. In an ongoing pilot study to determine the usefulness of this technique, PET is compared with computerized tomography (CT) for the preoperative staging of colorectal carcinoma.
Sixteen patients were evaluated with both PET and CT of the abdomen and pelvis. Results were compared with operative and histopathologic findings. Fifteen malignant lesions were found in 16 patients by histology. PET had a positive predictive value of 93 percent and a negative predictive value of 50 percent. By comparison CT had a positive predictive value of 100 percent and a negative predictive value of 27 percent.
These preliminary results indicate that PET has increased sensitivity for staging colorectal carcinoma, whereas CT has higher specificity. The predictive value of a positive PET compares favorably with CT. Furthermore, the predictive accuracy for detection of colorectal carcinoma is 83 percent for PET and 56 percent for CT.
正电子发射断层扫描（PET）是一种基于体内细胞代谢的成像技术。通过使用氟-18脱氧葡萄糖来检测肿瘤细胞中增加的葡萄糖代谢。在一项正在进行的确定该技术实用性的初步研究中，将PET与计算机断层扫描（CT）用于结直肠癌的术前分期比较。
对16例患者进行了腹部和骨盆的PET及CT检查。将结果与手术及组织病理学结果进行比较。16例患者经组织学检查发现15个恶性病变。PET的阳性预测值为93%，阴性预测值为50%。相比之下，CT的阳性预测值为100%，阴性预测值为27%。
这些初步结果表明，PET对结直肠癌分期的敏感性增加，而CT具有更高的特异性。PET阳性的预测价值与CT相当。此外，PET检测结直肠癌的预测准确率为83%，CT为56%。
