Lidove O, Cacoub P, Hausfater P, Wechsler B, Frances C, Leger J M, Piette J C
Service de Médecine Interne, Centre Hospitalier Universitaire Pitié-Salpêtrière, Paris.
Gastroenterol Clin Biol. 1999 Mar;23(3):403-6.
We report 4 cases of peripheral neuropathy induced by type II IgM kappa mixed cryoglobulinemia associated with hepatitis C virus infection. Worsening of peripheral neuropathy was observed 2 to 13 weeks after the initiation of interferon. The evolution of the hepatic and neurological diseases did not coincide, as all patients decreased or normalized transaminases with interferon. After stopping interferon, peripheral neuropathy worsened (1 case), stabilized (1 case), improved (2 cases). Low doses of interferon alpha may cause worsening of peripheral neuropathy in patients with hepatitis C virus infection associated with mixed cryoglobulinemia.
我们报告了4例由与丙型肝炎病毒感染相关的II型IgMκ混合冷球蛋白血症引起的周围神经病变。在开始使用干扰素后2至13周观察到周围神经病变恶化。肝脏和神经疾病的进展并不一致，因为所有患者使用干扰素后转氨酶均降低或恢复正常。停用干扰素后，周围神经病变恶化（1例）、稳定（1例）、改善（2例）。低剂量的干扰素α可能会使与混合冷球蛋白血症相关的丙型肝炎病毒感染患者的周围神经病变恶化。
