Three-dimensional artifact induced by projection weighting and misalignment.

In recent years, the use of computer graphic techniques to produce three-dimensional (3-D) and reformatted images from a set of axial computed tomography (CT) images has gained significant interest. In most cases, the CT images are generated with the projection data set weighted prior to reconstruction, to combat motion artifacts, data inconsistency, or redundant data samples. In this paper, we investigate the potential bias introduced to the reconstruction as a result of the interaction of the projection weights and the isocenter misalignment (ISM). We demonstrate that when the weights applied to the conjugate rays are significantly different, bias will result which favors the sample with a higher weight. Although the error is not easily detected in axial CT images, it can be quite visible in 3-D or multiplanar reformatted (MPR) images. In this paper, we first present a theoretical framework to analyze and predict the bias. The theoretical prediction is validated by both computer simulations and phantom experiments. Several schemes to combat this artifact are subsequently presented; and their effectiveness is demonstrated.