Gawande V V, Wahab S N, Zodpey S P, Vasudeo N D
Dept. of Preventive and Social Medicine, Govt. Medical College and Hospital, Nagpur, Maharashtra, India.
Indian J Cancer. 1998 Dec;35(4):164-70.
The present hospital based, group matched case control study was carried out at Gynaecology clinic, Govt. Medical College Hospital, Nagpur, to study risk factors for cancer cervix and investigate their independent and interactive role in the outcome of cervical cancer. The study included 230 cases of cancer cervix and equal number of controls, group matched for age. Univariate analysis included 17 hypothesised risk factors for cancer cervix and identified significance of 10 risk factors. However multiple logistic regression (MLR) analysis recognised and confirmed the significance of illiteracy, poor genital hygiene, long duration of married life, multiparity and early menarche in the ultimate outcome of cancer cervix. Estimates of Attributable Risk Proportions (ARP) and Population Attributable Risk Proportion (PARP) endorsed the etiological and preventable role of these risk factors, respectively. Considering the public health impact of elimination of these risk factors on the cancer cervix problem in this population, development of a preventive strategy based on these risk factors would be an appropriate step towards curtailment of this "Biggest Scourge of womankind".
本基于医院的群组匹配病例对照研究在那格浦尔政府医学院医院妇科门诊开展，旨在研究宫颈癌的危险因素，并调查它们在宫颈癌发病过程中的独立作用和交互作用。该研究纳入了230例宫颈癌病例和数量相等的对照组，两组在年龄上进行了匹配。单因素分析纳入了17个假设的宫颈癌危险因素，并确定了10个危险因素的显著性。然而，多因素逻辑回归（MLR）分析认可并证实了文盲、生殖器卫生差、婚姻生活持续时间长、多产和初潮早对宫颈癌最终发病的显著性。归因风险比例（ARP）和人群归因风险比例（PARP）的估计分别支持了这些危险因素的病因学作用和可预防性。考虑到消除这些危险因素对该人群宫颈癌问题的公共卫生影响，基于这些危险因素制定预防策略将是朝着减少这种“女性最大祸害”迈出的合适一步。
