Donly K J, Stufflebeam M, García-Godoy F
Department of Pediatric Dentistry, University of Texas Health Science Center, San Antonio 78284-7888, USA.
Am J Dent. 1998 Aug;11(4):151-3.
To evaluate the in vitro caries inhibition effects of 1.23% APF foam topical fluoride treatment of cavity preparations, prior to restoration placement and after restoration placement.
Sixty standardized Class V preparations were placed in molars. Randomly, 40 teeth received an amalgam restoration: Twenty other teeth had 1cc 1.23% APF foam applied to preparation surfaces for 1 minute, then an amalgam restoration was placed. The APF was not rinsed away prior to restoration, it was displaced by the pressure of the amalgam being condensed into the preparation. Twenty of the initial 40 amalgam restorations had 1 cc 1.23% APF foam applied to the external tooth/restoration margins for 4 minutes, the remaining 20 amalgam restorations acted as the controls. Acid-resistant varnish was placed, leaving 1 mm of tooth adjacent to restoration margins exposed. All specimens were subjected to an artificial caries challenge (pH 4.4) for 5 days. Sections of 100 microns were cut longitudinally through the restored margins, photographed under polarized light microscopy, then demineralized areas adjacent to restoration margins were quantitated.
Results demonstrated the mean (+/- S.D.) area (microns 2) of demineralization 100 microns from the restoration margins to be: amalgam 10,221 +/- 524, amalgam with 1-minute APF over preparation 529 +/- 557, amalgam with 4-minute APF over external surface 736 +/- 359. ANOVA and Duncan's (P < 0.05) indicated both 1.23% APF foam topical fluoride treatment regimens exhibited significantly less demineralization at restoration margins than the non-treated amalgam control. There was no significant difference between the two fluoride placement regimens examined in this study.
评估在窝洞预备后、修复体放置前以及放置后，用1.23%的酸性磷酸氟（APF）泡沫进行局部氟化物治疗对窝洞预备的体外防龋效果。
在磨牙上制备60个标准化的V类洞。随机选取40颗牙齿进行银汞合金修复：另外20颗牙齿在窝洞预备表面涂抹1毫升1.23%的APF泡沫1分钟，然后进行银汞合金修复。在修复前未冲洗掉APF，它被银汞合金填入窝洞时的压力所取代。最初40个银汞合金修复体中的20个在牙齿/修复体边缘外部涂抹1毫升1.23%的APF泡沫4分钟，其余20个银汞合金修复体作为对照。放置耐酸清漆，使修复体边缘相邻的1毫米牙齿暴露在外。所有标本接受5天的人工龋损挑战（pH 4.4）。沿修复体边缘纵向切割100微米厚的切片，在偏光显微镜下拍照，然后对修复体边缘附近的脱矿区域进行定量分析。
结果显示，距修复体边缘100微米处脱矿的平均（±标准差）面积（平方微米）为：银汞合金修复体为10221±524，窝洞预备前用1分钟APF处理的银汞合金修复体为529±557，修复体外部表面用4分钟APF处理的银汞合金修复体为736±359。方差分析和邓肯检验（P<0.05）表明，两种1.23% APF泡沫局部氟化物治疗方案在修复体边缘处的脱矿情况均显著少于未处理的银汞合金对照组。本研究中检测的两种氟化物应用方案之间无显著差异。
