Carlsson S, Persson P G, Alvarsson M, Efendic S, Norman A, Svanström L, Ostenson C G, Grill V
Division of Epidemiology, Karolinska University Hospital, Stockholm, Sweden.
Diabetes Care. 1999 Jul;22(7):1043-7. doi: 10.2337/diacare.22.7.1043.
To investigate the association between low birth weight and glucose intolerance in relation to family history of diabetes.
We conducted a population-based cross-sectional study of 2,237 men born in 1938-1957 in four municipalities in the outskirts of Stockholm, 50% of whom had a family history of diabetes (at least one first-degree or two second-degree relatives with diabetes). Oral glucose tolerance testing detected 35 cases of type 2 diabetes, 102 cases of impaired glucose tolerance, and 57 cases of impaired fasting glucose.
In subjects without a family history of diabetes, low (< or = 3,000 g) birth weight was associated with an odds ratio of 2.3 (95% confidence intervals = 0.4-14.4) for diabetes, 1.8 (0.7-4.3) for impaired glucose tolerance, and 3.3 (1.0-10.4) for impaired fasting glucose. In subjects with a family history of diabetes, the corresponding figures were approximately similar, except for diabetes, for which the odds ratio was 5.4 (2.0-14.9). For men with low birth weight in combination with a family history of diabetes, the odds ratio was 10.9 (2.9-41.2) for diabetes, 2.4 (1.1-5.6) for impaired glucose tolerance, and 5.9 (2.1-16.3) for impaired fasting glucose.
This study indicated that low birth weight is associated with type 2 diabetes, impaired glucose tolerance, and impaired fasting glucose in men. This finding was most pronounced in subjects with diabetes in the family, but it was also indicated in those without a family history of diabetes. Men with the combination of low birth weight and family history of diabetes seem to be at particularly high risk of developing type 2 diabetes.
研究低出生体重与糖耐量异常之间的关联，并探讨其与糖尿病家族史的关系。
我们对斯德哥尔摩郊区四个市1938 - 1957年出生的2237名男性进行了基于人群的横断面研究，其中50%有糖尿病家族史（至少有一位一级亲属或两位二级亲属患糖尿病）。口服葡萄糖耐量试验检测出2型糖尿病患者35例、糖耐量受损患者102例、空腹血糖受损患者57例。
在无糖尿病家族史的受试者中，低出生体重（≤3000克）与患糖尿病的比值比为2.3（95%置信区间 = 0.4 - 14.4），与糖耐量受损的比值比为1.8（0.7 - 4.3），与空腹血糖受损的比值比为3.3（1.0 - 10.4）。在有糖尿病家族史的受试者中，除糖尿病外，相应数值大致相似，糖尿病的比值比为5.4（2.0 - 14.9）。对于低出生体重且有糖尿病家族史的男性，患糖尿病的比值比为10.9（2.9 - 41.2），糖耐量受损的比值比为2.4（1.1 - 5.6），空腹血糖受损的比值比为5.9（2.1 - 16.3）。
本研究表明，低出生体重与男性2型糖尿病、糖耐量受损及空腹血糖受损有关。这一发现在有糖尿病家族史的受试者中最为明显，但在无糖尿病家族史的受试者中也有体现。低出生体重且有糖尿病家族史的男性似乎患2型糖尿病的风险特别高。
