日本家族性胃癌家系中E-钙黏蛋白基因的罕见种系突变。
Infrequent germ-line mutation of the E-cadherin gene in Japanese familial gastric cancer kindreds.
作者信息
Iida S, Akiyama Y, Ichikawa W, Yamashita T, Nomizu T, Nihei Z, Sugihara K, Yuasa Y
机构信息
Second Department of Surgery, Tokyo Medical and Dental University School of Medicine, Japan.
出版信息
Clin Cancer Res. 1999 Jun;5(6):1445-7.
Germ-line mutation of the E-cadherin gene was reported in familial gastric cancer (FGC) kindreds from New Zealand. Therefore, we analyzed all of the exons of E-cadherin by PCR-single-strand conformational polymorphism analysis in 16 patients from 14 Japanese FGC kindreds. However, no germ-line mutation was detected, suggesting that a predisposition to FGCs by E-cadherin gene mutation is infrequent in Japanese cases.
在来自新西兰的家族性胃癌（FGC）家族中报道了E-钙黏蛋白基因的种系突变。因此，我们通过聚合酶链反应-单链构象多态性分析，对来自14个日本FGC家族的16例患者的E-钙黏蛋白所有外显子进行了分析。然而，未检测到种系突变，这表明在日本病例中，E-钙黏蛋白基因突变导致FGC易感性的情况并不常见。
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