Al-Hussaini Abdulrahman, Alghamdi Salem, Alsaaran Rasha, Al-Kasim Fawaz, Habib Zakaria, Ourfali Nouri
Division of Pediatric Gastroenterology, Hepatology & Nutrition, Children's Hospital, University of King Saud for Health Sciences, King Fahad Medical City, P.O. Box 59046, Riyadh 11525, Saudi Arabia.
Department of Pediatrics, College of Medicine, King Saud University and King Khalid University Hospital, Riyadh, Saudi Arabia.
Case Rep Gastrointest Med. 2014;2014:527471. doi: 10.1155/2014/527471. Epub 2014 Jan 14.
Gastric carcinoma is extremely rare in children representing only 0.05% of all gastrointestinal malignancies. Here, we report the first pediatric case of gastric cancer presenting with gastric outlet obstruction. Upper endoscopy revealed a markedly thickened antral mucosa occluding the pylorus and a clean base ulcer 1.5 cm × 2 cm at the lesser curvature of the stomach. The narrowed antrum and pylorus underwent balloon dilation, and biopsy from the antrum showed evidence of Helicobacter pylori gastritis. The biopsy taken from the edge of the gastric ulcer demonstrated signet-ring-cell type infiltrate consistent with gastric adenocarcinoma. At laparotomy, there were metastases to the liver, head of pancreas, and mesenteric lymph nodes. Therefore, the gastric carcinoma was deemed unresectable. The patient died few months after initiation of chemotherapy due to advanced malignancy. In conclusion, this case report underscores the possibility of gastric adenocarcinoma occurring in children and presenting with gastric outlet obstruction.
胃癌在儿童中极为罕见,仅占所有胃肠道恶性肿瘤的0.05%。在此,我们报告首例表现为胃出口梗阻的儿童胃癌病例。上消化道内镜检查显示,胃窦黏膜明显增厚,阻塞幽门,胃小弯处有一个1.5厘米×2厘米的基底干净的溃疡。狭窄的胃窦和幽门接受了球囊扩张,胃窦活检显示有幽门螺杆菌胃炎的证据。取自胃溃疡边缘的活检显示印戒细胞型浸润,符合胃腺癌。剖腹手术时,发现已有肝、胰头和肠系膜淋巴结转移。因此,该胃癌被认为无法切除。患者在开始化疗几个月后因晚期恶性肿瘤死亡。总之,本病例报告强调了儿童发生胃腺癌并表现为胃出口梗阻的可能性。