Cirelli C, Pompeiano M, Tononi G
The Neurosciences Institute, 10640 J. J. Hopkins Drive, San Diego, CA 92121, USA.
Science. 1996 Nov 15;274(5290):1211-5. doi: 10.1126/science.274.5290.1211.
Several transcription factors are expressed at higher levels in the waking than in the sleeping brain. In experiments with rats, the locus coeruleus, a noradrenergic nucleus with diffuse projections, was found to regulate such expression. In brain regions depleted of noradrenergic innervation, amounts of c-Fos and nerve growth factor-induced A after waking were as low as after sleep. Phosphorylation of cyclic adenosine monophosphate response element-binding protein was also reduced. In contrast, electroencephalographic activity was unchanged. The reduced activity of locus coeruleus neurons may explain why the induction of certain transcription factors, with potential effects on plasticity and learning, does not occur during sleep.
几种转录因子在清醒大脑中的表达水平高于睡眠大脑。在对大鼠的实验中，发现蓝斑核（一个具有弥散投射的去甲肾上腺素能核团）可调节这种表达。在去甲肾上腺素能神经支配缺失的脑区，清醒后c-Fos和神经生长因子诱导蛋白A的量与睡眠后一样低。环磷酸腺苷反应元件结合蛋白的磷酸化也减少。相比之下，脑电图活动没有变化。蓝斑核神经元活动的降低可能解释了为什么对可塑性和学习有潜在影响的某些转录因子在睡眠期间不会被诱导产生。
