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用于硼中子俘获疗法(BNCT)和硼中子俘获增强裂变中子疗法(BNCEFNT)的硼中子俘获反应剂量测定法。

Dosimetry of the boron neutron capture reaction for BNCT and BNCEFNT.

作者信息

Burmeister J, Kota C, Maughan R L

机构信息

Gershenson Radiation Oncology Center, Karmanos Cancer Institute, Harper Hospital, Detroit, USA.

出版信息

Strahlenther Onkol. 1999 Jun;175 Suppl 2:115-8. doi: 10.1007/BF03038908.

Abstract

The use of paired proportional counters, constructed from A-150 tissue equivalent plastic (TEP) and A-150 TEP loaded with an appropriate amount of 10B (50 to 200 ppm), for the dosimetry of the boron neutron capture reaction has been investigated for several years at the Gershenson Radiation Oncology Center. This method has been used for determining the dose components (fast neutron, gamma ray and boron capture product dose) in both Boron Neutron Capture Therapy (BNCT) beams and in beams proposed for boron neutron capture enhancement of fast neutron therapy (BNCEFNT). A disadvantage of this method, when standard 1/2" diameter Rossi type proportional counters are used, is that the beam intensity must be relatively low in order to avoid saturation effects (pulse pile-up) in the counter. This is a major problem if measurements are to be made in a reactor beam, since reducing the beam intensity generally results in a change in the neutron spectrum. In order to overcome this problem, miniature cylindrical proportional counters have been developed which may be used in high intensity beams. The operational characteristics of these counters are compared with the standard 1/2" spherical counters. A further disadvantage of proportional counters is the relatively long time it takes to collect data, particularly if detailed information (depth-dose curves and beam profiles) is required. This problem could be overcome by using a set of ionization chambers (an A-150 TEP chamber, a Mg chamber and a Mg chamber with a 25 microns boron loaded inner wall) which can be scanned in a water phantom. After calibration against the paired proportional counters it should be possible to extract the fast neutron, gamma ray and boron neutron capture product doses from measurements made with these three ionization chambers. A set of such chambers has been used to make preliminary measurements in a fast neutron beam and the results of these measurements are presented.

摘要

在格申森放射肿瘤中心,使用由A - 150组织等效塑料(TEP)和负载适量¹⁰B(50至200 ppm)的A - 150 TEP制成的成对比例计数器进行硼中子俘获反应剂量测定的研究已经开展了数年。该方法已用于确定硼中子俘获疗法(BNCT)束以及为增强快中子疗法的硼中子俘获(BNCEFNT)所提议的束中的剂量成分(快中子、伽马射线和硼俘获产物剂量)。当使用标准的1/2英寸直径的罗西型比例计数器时,该方法的一个缺点是束流强度必须相对较低,以避免计数器中的饱和效应(脉冲堆积)。如果要在反应堆束中进行测量,这是一个主要问题,因为降低束流强度通常会导致中子能谱发生变化。为了克服这个问题,已经开发出了可用于高强度束的微型圆柱形比例计数器。将这些计数器的运行特性与标准的1/2英寸球形计数器进行了比较。比例计数器的另一个缺点是收集数据所需的时间相对较长,特别是如果需要详细信息(深度剂量曲线和束流剖面)的话。这个问题可以通过使用一组电离室(一个A - 150 TEP室、一个镁室和一个内壁负载25微米硼的镁室)来克服,这些电离室可以在水模体中进行扫描。在根据成对比例计数器进行校准之后,应该能够从用这三个电离室进行的测量中提取快中子、伽马射线和硼中子俘获产物剂量。已经使用一组这样的电离室在快中子束中进行了初步测量,并给出了这些测量结果。

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