来自嗜藻真菌德氏德氏霉的罕见倍半萜类化合物。

Rare sesquiterpenes from the algicolous fungus Drechslera dematioidea.

作者信息

Osterhage Claudia, König Gabriele M, Höller Ulrich, Wright Anthony D

机构信息

Institute for Pharmaceutical Biology, Technical University of Braunschweig, Mendelssohnstrasse 1, 38106 Braunschweig, Germany.

出版信息

J Nat Prod. 2002 Mar;65(3):306-13. doi: 10.1021/np010092l.

DOI:10.1021/np010092l

PMID:11908970

Abstract

From the inner tissue of the marine red alga Liagora viscida the fungus Drechslera dematioidea was isolated. After mass cultivation, the fungus was investigated for its secondary metabolite content, and 10 new sesquiterpenoids [isosativenetriol (1), drechslerines A (2) and B (3), 9-hydroxyhelminthosporol (5), drechslerines C-G (6-10), and sativene epoxide (12)] were isolated. Compounds 8 and 10 exhibited antiplasmodial activity against Plasmodium falciparum strains K1 and NF54. The known compounds helminthosporol (4), cis-sativenediol (11), isocochlioquinone A (14), isocochlioquinone C (15), and cochlioquinone B (16) were also isolated. All structures were elucidated using spectroscopic methods, mainly 1D and 2D NMR and MS.

摘要

从海洋红藻粘叶藻的内部组织中分离出了真菌德氏霉。大规模培养后，对该真菌的次生代谢产物含量进行了研究，分离出了10种新的倍半萜类化合物[异萨蒂内三醇(1)、德氏菌素A(2)和B(3)、9-羟基蠕孢醇(5)、德氏菌素C-G(6-10)以及萨蒂烯环氧化物(12)]。化合物8和10对恶性疟原虫菌株K1和NF54表现出抗疟活性。还分离出了已知化合物蠕孢醇(4)、顺式萨蒂二醇(11)、异球石醌A(14)、异球石醌C(15)和球石醌B(16)。所有结构均通过光谱方法进行了阐明，主要是一维和二维核磁共振以及质谱。