Rubin S A, Snoy P J, Wright K E, Brown E G, Reeve P, Beeler J A, Carbone K M
Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA.
J Infect Dis. 1999 Aug;180(2):521-5. doi: 10.1086/314905.
Wild type mumps viruses are highly neurotropic and a frequent cause of aseptic meningitis in unvaccinated humans. To test whether attenuated mumps viruses used in the manufacture of mumps vaccines have neurovirulent properties, a monkey neurovirulence safety test (MNVT) is performed. However, results with several mumps virus MNVTs have raised questions as to whether the test can reliably discriminate neurovirulent from nonneurovirulent mumps virus strains. Here, various mumps virus strains representing a wide range of neuropathogenicity were tested in a standardized MNVT. A trend of higher neurovirulence scores was observed in monkeys inoculated with wild type mumps virus versus vaccine strains, although differences were not statistically significant. Results indicated the need for further examination and refinement of the MNVT or for development of alternative MNVTs.
野生型腮腺炎病毒具有高度嗜神经性，是未接种疫苗人群无菌性脑膜炎的常见病因。为检测用于生产腮腺炎疫苗的减毒腮腺炎病毒是否具有神经毒力特性，需进行猴神经毒力安全性试验（MNVT）。然而，多项腮腺炎病毒MNVT试验结果引发了关于该试验能否可靠区分神经毒力腮腺炎病毒株和非神经毒力腮腺炎病毒株的疑问。在此，在标准化的MNVT中对代表广泛神经致病性的多种腮腺炎病毒株进行了测试。与接种疫苗株的猴子相比，接种野生型腮腺炎病毒的猴子的神经毒力得分有更高的趋势，尽管差异无统计学意义。结果表明需要进一步检查和完善MNVT或开发替代的MNVT。
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