Moore P A, Belvedere O, Orr A, Pieri K, LaFleur D W, Feng P, Soppet D, Charters M, Gentz R, Parmelee D, Li Y, Galperina O, Giri J, Roschke V, Nardelli B, Carrell J, Sosnovtseva S, Greenfield W, Ruben S M, Olsen H S, Fikes J, Hilbert D M
Human Genome Sciences, 9410 Key West Avenue, Rockville, MD 20850, USA.
Science. 1999 Jul 9;285(5425):260-3. doi: 10.1126/science.285.5425.260.
The tumor necrosis factor (TNF) superfamily of cytokines includes both soluble and membrane-bound proteins that regulate immune responses. A member of the human TNF family, BLyS (B lymphocyte stimulator), was identified that induced B cell proliferation and immunoglobulin secretion. BLyS expression on human monocytes could be up-regulated by interferon-gamma. Soluble BLyS functioned as a potent B cell growth factor in costimulation assays. Administration of soluble recombinant BLyS to mice disrupted splenic B and T cell zones and resulted in elevated serum immunoglobulin concentrations. The B cell tropism of BLyS is consistent with its receptor expression on B-lineage cells. The biological profile of BLyS suggests it is involved in monocyte-driven B cell activation.
细胞因子的肿瘤坏死因子（TNF）超家族包括调节免疫反应的可溶性和膜结合蛋白。已鉴定出人类TNF家族的一个成员BLyS（B淋巴细胞刺激因子），它可诱导B细胞增殖和免疫球蛋白分泌。干扰素-γ可上调人单核细胞上的BLyS表达。在共刺激试验中，可溶性BLyS发挥了强大的B细胞生长因子作用。给小鼠注射可溶性重组BLyS会破坏脾脏B细胞和T细胞区，并导致血清免疫球蛋白浓度升高。BLyS对B细胞的嗜性与其在B谱系细胞上的受体表达一致。BLyS的生物学特性表明它参与单核细胞驱动的B细胞活化。
