Cancro Michael P
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6082, USA.
Immunol Rev. 2004 Dec;202:237-49. doi: 10.1111/j.0105-2896.2004.00212.x.
Discovery and characterization of the tumor necrosis factor (TNF) family member B-lymphocyte stimulator (BLyS) has opened a novel chapter in the role of TNF family members in the homeostatic control of lymphocyte populations. BLyS and its sister cytokine APRIL (a proliferation-inducing ligand) act primarily as soluble trimers and serve to regulate the steady-state numbers of nearly all B-cell compartments. This homeostatic regulation is accomplished through the regulation of B-cell production rates, selection thresholds, and lifespan. Differential expression of the three BLyS receptors during differentiation and activation provides related yet distinct homeostatic niches for follicular, marginal zone, and memory B-cell subsets.
肿瘤坏死因子（TNF）家族成员B淋巴细胞刺激因子（BLyS）的发现与特性研究，为TNF家族成员在淋巴细胞群体稳态控制中的作用开启了新的篇章。BLyS及其姐妹细胞因子增殖诱导配体（APRIL）主要以可溶性三聚体形式发挥作用，用于调节几乎所有B细胞亚群的稳态数量。这种稳态调节是通过调控B细胞的产生速率、选择阈值和寿命来实现的。在分化和激活过程中，三种BLyS受体的差异表达为滤泡性B细胞、边缘区B细胞和记忆B细胞亚群提供了相关但又不同的稳态微环境。
