Meffre P
Ecole Nationale Supérieure de Chimie de Paris, France.
Amino Acids. 1999;16(3-4):251-72. doi: 10.1007/BF01388171.
Strategies for the synthesis of optically active aspartaldehyde derivatives are reviewed. Most of them are using the chiral pool: allylglycine or naturally occurring homoserine, aspartic acid or methionine and side chain modifications. This will be developed in the first part. Some other original routes are also displayed in the second part. Different aspects of each strategy are discussed: the nature and number of steps, the problem of protecting groups, the price and availability of starting materials. Some synthetic applications of such interesting chiral synthons are shown in the last part.
本文综述了光学活性天冬醛衍生物的合成策略。其中大多数策略采用手性源：烯丙基甘氨酸或天然存在的高丝氨酸、天冬氨酸或甲硫氨酸以及侧链修饰。这将在第一部分展开论述。第二部分还展示了一些其他的原创路线。文中讨论了每种策略的不同方面：步骤的性质和数量、保护基问题、起始原料的价格和可得性。最后一部分展示了此类有趣的手性合成子的一些合成应用。
