1-氨基-2,5-脱水-1-脱氧-D-甘露糖醇及其芳基氨基衍生物的简便立体专一性合成。
An easy stereospecific synthesis of 1-amino-2,5-anhydro-1-deoxy-D-mannitol and arylamino derivatives.
作者信息
Claustre S, Bringaud F, Azéma L, Baron R, Périé J, Willson M
机构信息
UMR CNRS 5623, Université Paul Sabatier, Toulouse, France.
出版信息
Carbohydr Res. 1999 Feb 28;315(3-4):339-44. doi: 10.1016/s0008-6215(99)00040-3.
Abstract
1-Amino-2,5-anhydro-1-deoxy-D-mannitol and a series of arylamino derivatives were prepared by nitrous acid deamination of 2-amino-2-deoxy-D-glucose and subsequent reductive amination of the resulting 2,5-anhydro-D-mannose. Some of these compounds showed an enhanced affinity for the hexose transporter of Trypanosoma brucei as compared to D-fructose.
摘要
通过对2-氨基-2-脱氧-D-葡萄糖进行亚硝酸脱氨反应，并对所得的2,5-脱水-D-甘露糖进行后续还原胺化反应，制备了1-氨基-2,5-脱水-1-脱氧-D-甘露糖醇及其一系列芳基氨基衍生物。与D-果糖相比，其中一些化合物对布氏锥虫的己糖转运蛋白表现出更高的亲和力。
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