Laccourreye O, Muscatello L, Gutierrez-Fonseca R, Seckin S, Brasnu D, Bonan B
Service d'Oto-rhino-laryngologie et de chirurgie cervico-faciale, Hôpital Laennec, Paris.
Ann Otolaryngol Chir Cervicofac. 1999 Jun;116(3):137-42.
Based upon an inception cohort of 30 patients with severe Frey's syndrome, after conservative parotidectomy, the technique and the results of intracutaneous injection of botulinum toxin type A are presented. The skin surface involved with Frey's syndrome was managed with intracutaneous injection of 2.5 international units of botulinum toxin type A per square centimeter. A minimum follow-up of 16 months was achieved. The only adverse side effect encountered was a temporary paresis of the upper lid noted in 2 patients. Frey's syndrome vanished within 2-5 days from the intracutaneous injection of botulinum toxin type A. Frey's syndrome was controlled in 53.2% of cases (17/30) after the initial injection of botulinum toxin type A. Five of the 13 patients with recurrence of Frey's syndrome elicited to undergo a watch and wait policy due to the lack of discomfort induced by the recurrence. The remaining eight patients with recurrence of Frey's syndrome were successfully managed with a secondary intracutaneous injection of botulinum toxin type A. Such preliminary data, together with the review of the literature suggests, that the intracutaneous injection of botulinum toxin type A should now be the first line treatment option in patients with severe Frey syndrome.
基于30例严重Frey综合征患者的初始队列，在进行保守性腮腺切除术后，介绍了皮内注射A型肉毒杆菌毒素的技术和结果。对Frey综合征累及的皮肤表面，每平方厘米皮内注射2.5国际单位A型肉毒杆菌毒素。实现了至少16个月的随访。唯一遇到的不良副作用是2例患者出现上睑暂时性麻痹。皮内注射A型肉毒杆菌毒素后，Frey综合征在2 - 5天内消失。初次注射A型肉毒杆菌毒素后，53.2%的病例（17/30）Frey综合征得到控制。13例Frey综合征复发患者中有5例因复发未引起不适而采取观察等待策略。其余8例Frey综合征复发患者通过再次皮内注射A型肉毒杆菌毒素成功治疗。这些初步数据以及文献综述表明，皮内注射A型肉毒杆菌毒素现在应成为严重Frey综合征患者的一线治疗选择。
