Hartl D M, Julieron M, LeRidant A-M, Janot F, Marandas P, Travagli J-P
Department of Otolaryngology-Head and Neck Surgery, Institut Gustave Roussy, Villejuif, France.
J Laryngol Otol. 2008 Oct;122(10):1100-4. doi: 10.1017/S0022215108001771. Epub 2008 Feb 21.
To measure patient-reported quality of life before and after botulinum toxin A treatment of post-parotidectomy Frey's syndrome (gustatory sweating).
A questionnaire concerning functional, social and emotional aspects of Frey's syndrome (14 questions, with responses on a zero to three point scale) was administered to 17 patients (13 women and four men) before and one month after intradermal injection of botulinum toxin A. Parotidectomy had been performed one to 19 years previously, for benign (n = 10) or malignant (n = 7) tumours, with gustatory sweating occurring a median of 15 months after surgery (range: one month to 14 years). Pre- and post-treatment quality of life scores were compared using Wilcoxon's test (p < 0.05).
Patients' reported functional quality of life improved significantly (p = 0.0004). Their social and emotional scores were not significantly modified (p = 0.155 and 0.142, respectively). Seven patients (41 per cent) found the injections painful, but all patients said that the effects were beneficial, that they would undergo new injections if necessary and that they would recommend this treatment to other patients. The benefit lasted over 1.5 years for 60 per cent of patients. No correlation was found between duration of the effect and the extent of parotidectomy (p = 0.067).
Botulinum toxin A significantly improved patients' functional quality of life, without significant improvement in their social or emotional quality of life, according to our questionnaire results. The duration of the effect was longer than the reported physiological effect of botulinum toxin A on acetylcholine receptors.
测量肉毒杆菌毒素A治疗腮腺切除术后味觉出汗综合征（味觉性出汗）前后患者报告的生活质量。
对17例患者（13例女性和4例男性）在皮内注射肉毒杆菌毒素A前及注射后1个月进行问卷调查，内容涉及味觉出汗综合征的功能、社交和情感方面（14个问题，回答采用0至3分制）。腮腺切除术于1至19年前进行，用于治疗良性（n = 10）或恶性（n = 7）肿瘤，味觉出汗综合征在手术后中位时间为15个月出现（范围：1个月至14年）。使用Wilcoxon检验比较治疗前后的生活质量评分（p < 0.05）。
患者报告的功能生活质量有显著改善（p = 0.0004）。他们的社交和情感评分没有显著变化（分别为p = 0.155和0.142）。7例患者（41%）觉得注射疼痛，但所有患者均表示效果有益，如有必要愿意接受再次注射，并会向其他患者推荐这种治疗方法。60%的患者效果持续超过1.5年。未发现效果持续时间与腮腺切除范围之间存在相关性（p = 0.067）。
根据我们的问卷调查结果，肉毒杆菌毒素A显著改善了患者的功能生活质量，但社交和情感生活质量没有显著改善。效果持续时间长于报道的肉毒杆菌毒素A对乙酰胆碱受体的生理作用持续时间。
