Murakami T, Murakami T, Su W D, Ohtsuka A, Abe K, Ninomiya Y
Department of Anatomy, Faculty of Medicine, Okayama University Medical School, Japan.
Arch Histol Cytol. 1999 May;62(2):199-204. doi: 10.1679/aohc.62.199.
As our previous study has indicated, perineuronal proteoglycans in the adult mouse brain are associated with some collagenous molecules which can be stained with Gömöri's ammoniacal silver and are resistant to hyaluronidase digestion. The present study demonstrated that these molecules are thoroughly digested with collagenase, and suggests that they represent a hyaluronic acid-binding domain of the ligand proteoglycans connecting the perineuronal proteoglycans and nerve cell surface glycoproteins.
正如我们之前的研究所表明的，成年小鼠大脑中的神经元周围蛋白聚糖与一些胶原分子相关，这些胶原分子可以用Gömöri氨银染色，并且对透明质酸酶消化具有抗性。本研究表明，这些分子能被胶原酶完全消化，并提示它们代表连接神经元周围蛋白聚糖和神经细胞表面糖蛋白的配体蛋白聚糖的透明质酸结合结构域。
