兴奋剂检测中提高成绩药物的毛细管气相色谱应用介绍

Introduction to the application of capillary gas chromatography of performance-enhancing drugs in doping control.

作者信息

Müller R K, Grosse J, Thieme D, Lang R, Teske J, Trauer H

机构信息

Institute of Doping Analysis, Kreischa, Germany.

出版信息

J Chromatogr A. 1999 May 28;843(1-2):275-85. doi: 10.1016/s0021-9673(99)00498-7.

DOI:10.1016/s0021-9673(99)00498-7

PMID:10399856

Abstract

Performance-enhancing drugs banned by antidoping rules are detected in doping control preferably by hyphenated chromatographic techniques, capillary gas chromatography in particular. Based on the prohibited classes of substances and on the general aspects of sample collection and preparation, a survey is given about the usual procedures of screening, identification and confirmation of the most important doping agents: stimulants, narcotics, anabolics, diuretics, beta-blockers. In addition to gas chromatography itself, the application of various MS techniques doping is outlined.

摘要

在兴奋剂检测中，禁用的提高成绩药物最好通过联用色谱技术，尤其是毛细管气相色谱法来检测。基于禁用物质的类别以及样品采集和制备的一般方面，对最重要的兴奋剂（兴奋剂、麻醉药品、合成代谢类固醇、利尿剂、β受体阻滞剂）的筛查、鉴定和确证的常规程序进行了综述。除了气相色谱本身，还概述了各种质谱技术在兴奋剂检测中的应用。