Szász G, Budvári-Bárány Z, Gergely A, Gyimesi-Forrás K
Semmelweis OTE, Gyógyszerészi Kémiai Intézet, Budapest.
Acta Pharm Hung. 1999 Jun;69(3):97-102.
The paper is addressed to the institute of Pharmaceutical Chemistry, Budapest, on the 50th anniversary of its foundation, paying tribute to Prof. Antal Végh, the first director of the Institute and his first deputy dr. László Auber and all the members of the Staff having merit in developing the research activity at the Department. After surveying the early papers published from the fifties through the seventies, concerning the profile of drug purity control, the factors increasing HPLC selectivity are shortly reviewed. In the concluding part of the paper, some recent results, as HPLC purity control methods suitable for compendial purposes (methylxanthines, opium alkaloids, tropane-alkaloids, enantiomer purity control of different drug compounds on glycoprotein and chirelcel columns) are summarized.
本文是为布达佩斯药物化学研究所成立50周年而作，向该研究所的第一任所长安塔尔·韦格教授及其第一副手拉兹洛·奥伯博士，以及所有在该部门研究活动发展中做出贡献的工作人员致敬。在回顾了五十年代至七十年代发表的有关药物纯度控制概况的早期论文后，简要回顾了提高高效液相色谱选择性的因素。在论文的结尾部分，总结了一些近期的成果，如适用于药典目的的高效液相色谱纯度控制方法（甲基黄嘌呤、鸦片生物碱、托烷生物碱、不同药物化合物在糖蛋白柱和手性柱上的对映体纯度控制）。
