el-Karaksy H, Hassanein B, Okasha S, Behairy B, Gadallah I
Paediatrics Departments, Faculty of Medicine, Cairo University, Egypt.
J Trop Pediatr. 1999 Jun;45(3):135-8. doi: 10.1093/tropej/45.3.135.
Human fascioliasis (HF) is an increasingly recognized public health problem in Egypt. During the past two years we diagnosed HF in 40 Egyptian children. Diagnosis was based on some or all of the following criteria: fever, tender hepatomegaly and high eosinophilia (febrile eosinophilic syndrome), presence of Fasciola hepatica eggs in stools, and/or serodiagnosis using the indirect haemagglutination test (IHAT). Eight of the 40 children had failed to respond to previous treatment with praziquantel. All children were treated with triclabendazole in a dose of 10 mg/kg as a single oral dose. Within 2 months, 31 children (78 per cent) were cured as evidenced by clinical well-being, normalization of eosinophil counts, Fasciola antibody titres, and absence of Fasciola hepatica eggs in stools. The remaining nine cases achieved clinical and laboratory cure after a second dose of triclabendazole. No side-effects were encountered in any of the cases. We conclude that triclabendazole is an effective, well-tolerated, easy to administer drug that should be considered in HF.
人体片形吸虫病（HF）在埃及是一个日益受到关注的公共卫生问题。在过去两年中，我们诊断出40例埃及儿童患有HF。诊断依据以下部分或全部标准：发热、肝脏压痛性肿大和高嗜酸性粒细胞增多（发热性嗜酸性粒细胞综合征）、粪便中存在肝片形吸虫卵，和/或使用间接血凝试验（IHAT）进行血清学诊断。40名儿童中有8名对先前的吡喹酮治疗无反应。所有儿童均接受了单剂量口服10mg/kg三氯苯达唑的治疗。在2个月内，31名儿童（78%）治愈，表现为临床状况良好、嗜酸性粒细胞计数、片形吸虫抗体滴度恢复正常，且粪便中无肝片形吸虫卵。其余9例在第二次服用三氯苯达唑后实现了临床和实验室治愈。所有病例均未出现副作用。我们得出结论，三氯苯达唑是一种有效、耐受性良好、易于给药的药物，在HF治疗中应予以考虑。
